Stevens-Johnson syndrome: A serious systemic (body-wide) allergic reaction with a characteristic rash involving the skin and mucous membranes, including the buccal mucosa (inside of the mouth), conjunctiva, and genital areas. Abbreviated SJS. The disease is due to a hypersensitive (allergic) reaction to one of a number of immunologic stimuli including drugs and infectious agents. Complications can include hepatitis, nephritis, gastrointestinal bleeding, pneumonia , arthritis , arthralgia, fever , and myalgia. The diagnosis of SJS is usually made when the characteristic rash appears 1 to 3 weeks after exposure to a known stimulus and it cannot be explained by another diagnosis. The treatment depends, in part, on the suspected precipitating cause. Also known as erythema multiforme major.
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Stevens Johnson Syndrome is a severe expression of a simple rash known as erythema multiforme. Stevens Johnson Syndrome is also known as erythema multiforme major. It affects all ages and genders including pediatric populations. The most severe form of Stevens Johnson Syndrome is Toxic Epidermal Necrolysis ( TENS ). Stevens Johnson Syndrome occurs twice as often in men as in women. Most cases of Stevens Johnson Syndrome appear in children and young adults under age 30. Females with Stevens Johnson Syndrome are twice as likely as males to develop TENS, and have an even higher chance if taking a category of drugs known as NSAIDs, non-steroidal anti-inflammatory agents.