There are no tell, tell signs of steroid abuse like there are with recreational drugs and this can make true abuse a little difficult to spot. However, here at we want to look at all aspects of steroid use, and in doing so, give you a better understanding of the topic at hand. Some of what you find will be nothing new, but much of it promises to be information that you’ve never been told. There is so much to discuss when it comes to this topic, and we guarantee when it comes to steroid abuse you may very well find what you once believed will rapidly change once exposed to the truth.
RAD 140 : Testolone studies are still being produced, but it has been known to have equal potency and effectiveness to that of LGD4033. Dosages ranged between 20mg to 30 mg per 24-36 hours for maximum skeletal muscle hypertrophy. Safe durations for research have been tolerated for up to 12 weeks, however, developing trials may indicate tolerance for up to 24 weeks. It is important to note that RAD140 systematically regulates the neuroexcitatory amino acid Kainate which activates glutamate receptors in the brain. Kainate acid’s role in neuronal cell death (specifically in the hippocampus) has been shown to be a primary contributor to Alzheimer’s disease. RAD140 has demonstrated positive results in the prevention of Kainate acid production and medical based research published by The Endocrine Society suggests RAD140 can improve brain health through neuroprotective properties in as little as 13 days (Jayaraman, 2014). This characteristic of nonsteroidal SARMs is not added in the General Benefits section of this article because it is exclusive only to RAD140.
Neural injections of Bromodeoxyuridine (BrdU) were applied to males of both groups to test for neurogenesis . Analysis showed that testosterone and dihydrotestosterone regulated adult hippocampal neurogenesis (AHN). Adult hippocampal neurogenesis was regulated through the androgen receptor in the wild-type male rats, but not in the TMF male rats. To further test the role of activated androgen receptors on AHN, flutamide , an antiandrogen drug that competes with testosterone and dihydrotestosterone for androgen receptors , and dihydrotestosterone were administered to normal male rats. Dihydrotestosterone increased the number of BrdU cells, while flutamide inhibited these cells.