Ketotifen is used by people suffering from wasting diseases partially caused by TNF-alpha. I think, however, its ability to lower TNF-alpha is going to be overshadowed by anabolic effects produced by anabolic steroids . In one study involving AIDS patients, combining Ketotifen and Oxymetholone ( Anadrol 50 ) showed that the Ketotifen didnt add much to the Oxymetholone induced weight gain (1). Hence, you are reading this profile in the "Ancilliaries" portion of this book, and not the "Fat - Burning" part, even though Ketotifen is typically used as part of a fat burning cycle including clen . Benadryl is simply too much cheaper and readily available to use Ketotifen in its place with Clen. However, for Post-Cycle-Therapy, Ketotifen and its ability to lower TNF-alpha, is a very valuable tool. You see, Hypogonadism ( low testosterone ) often accompanies elevated TNF-alpha levels (6), and after a cycle of anabolic steroids , you are going to be in a hypogonadal state, with elevated TNF-alpha. Thus, taking Ketotifen with your PCT is probably a very good idea. I recommend 1-3mgs/day before bed because this stuff will make you pretty drowsy.