A pain reliever may be the first thing you reach for when you come down with a cold, and with good reason. "Pain relievers for coughs and cold can be very effective," Alonzo said. They can also help with fever. Anti-inflammatory meds like Advil or Motrin (ibuprofen) or Aleve (naproxen) have the advantage of reducing tissue inflammation, but you should take Tylenol (acetaminophen) instead if you're taking blood thinners to prevent blood clots or if you have stomach problems, congestive heart failure, or asthma and nasal polyps.
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