For minor cases, some over-the-counter products can reduce itching and skin redness, according to the Cleveland Clinic. These include oral antihistamines, topical antibacterial and antifungal creams, and topical creams or ointments that contain the steroid cortisone, which reduces inflammation. More severe cases warrant prescription-strength cortisone products, including pills and topical creams. Additionally, the . Food and Drug Administration approved a new class of drugs called topical immunomodulators (TIMs), which alter the body's response to allergens.