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The origin of the name tretinoin is uncertain,   although several sources agree (one with probability,  one with asserted certainty  ) that it probably comes from trans- + retinoic [acid] + -in , which is plausible given that tretinoin is the all-trans isomer of retinoic acid . The name isotretinoin is the same root tretinoin plus the prefix iso- . Regarding pronunciation, the following variants apply equally to both tretinoin and isotretinoin . Given that retinoic is pronounced / ˌ r ɛ t ɪ ˈ n oʊ ɪ k / ,     it is natural that / ˌ t r ɛ t ɪ ˈ n oʊ ɪ n / is a commonly heard pronunciation. Dictionary transcriptions also include / ˌ t r ɪ ˈ t ɪ n oʊ ɪ n / ( tri- TIN -oh-in )   and / ˈ t r ɛ t ɪ n ɔɪ n / .