Intra articular corticosteroid injection pain relief in osteoarthritis of the hip

Intramuscular Injection: Provides an extended duration of therapeutic effect and fewer side effects of the kind associated with oral corticosteroid therapy, particularly gastro-intestinal reactions such as peptic ulceration. Studies indicate that, following a single intramuscular dose of 80 mg triamcinolone acetonide, adrenal suppression occurs within 24 - 48 hours and then gradually returns to normal, usually in approximately three weeks. This finding correlates closely with the extended duration of therapeutic action of triamcinolone acetonide.

A total of 821 subjects were screened for the study, and 588 subjects were randomized. Approximately 88% of the randomized subjects completed the study, with similar proportions completing in each treatment group. Sixty-eight (%) subjects discontinued the randomization /treatment phase prematurely: 34 (%) in the saline group and 34 (%) in the EUFLEXXA group. The most common reasons for discontinuation were the subject's withdrawing consent 25 (%) and AEs 17 (%). A total of 433 (%) subjects entered the open-label extension study.

Cartilaginous intra-articular bodies float freely within the synovial fluid, which they require for nutrition and growth.  Progressive enlargement and ossification occur with time.  If they remain free, they continue to grow larger and more calcified.  In severe cases, they may occupy the entire joint space or penetrate to adjacent tissues.  Alternately, they can deposit in the synovial lining, reestablish a blood supply, and become replaced by bone.  On occasion, synovial reattachment can lead to complete reabsorption of the cartilage fragment.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Intra articular corticosteroid injection pain relief in osteoarthritis of the hip

intra articular corticosteroid injection pain relief in osteoarthritis of the hip

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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