Pretty severe means you don’t respond to the treatment. I didn’t. Most women respond to the hormone supplements and at least have a monthly cycle. I haven’t had one since college, even with pills. I get damn tired of having to prove what I ate, how I exercised and how I live just to get medical professionals to treat me with anything resembling respect. I mentioned a surgeon’s screw up: in a few years, I’ll need an organ transplant thanks to that doctor. Of course, that assumes I can get one: the first doctor I saw at the nearest regional “center of excellence”
MacFarlane has served as an executive producer during the show's entire history, and also functions as a creative consultant. The first executive producers were David Zuckerman ,  Lolee Aries , David Pritchard, and Mike Wolf.  Family Guy has had many executive producers in its history, including Daniel Palladino , Kara Vallow , and Danny Smith . David A. Goodman joined the show as a co-executive producer in season three, and eventually became an executive producer.  Alex Borstein , who voices Lois , worked as an executive and supervising producer for the fourth and fifth seasons.