# Cox-2 inhibition non steroidal anti-inflammatory drugs

In biochemistry , suicide inhibition , also known as suicide inactivation or mechanism-based inhibition , is an irreversible form of enzyme inhibition that occurs when an enzyme binds a substrate analogue and forms an irreversible complex with it through a covalent bond during the normal catalysis reaction. The inhibitor binds to the active site where it is modified by the enzyme to produce a reactive group that reacts irreversibly to form a stable inhibitor-enzyme complex. This usually uses a prosthetic group or a coenzyme , forming electrophilic alpha and beta unsaturated carbonyl compounds and imines .

PhophoenolPyruvate → k i n a s e P y r u v a t e Pyruvate → i n h i b i t o r n o n c o m p e t i t i v e Alanine {\displaystyle {\ce {PhophoenolPyruvate->[Pyruvate][kinase]Pyruvate->[noncompetitive][inhibitor]Alanine}}}