AIM2 is referred to as the DNA inflammasome for its ability to detect foreign dsDNA , using a HIN200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) domain (encoded by IFI16 ) attached to a PYD , which it uses to recruit the adaptor protein ASC during inflammasome formation.    AIM2 binds dsDNA with its C-terminal domain.    The PYDdomain of AIM2 homotypically interacts by PYD-PYD interactions with ASC . The ASC CARD domain recruits procaspase-1 into the complex. Caspase-1 activates maturation of proinflammatory cytokines ( IL-1b , IL-18 ). AIM2 is activated by viral dsDNA, bacterial dsDNA and also aberrant host dsDNA.   Activation of the AIM2 is supposed to play role in autoimmune responses during the autoimmune disease systematic lupus erythematosus . AIM2 inflammasome is also activated by pharmacological disruption of nuclear envelope integrity.